Capcom missed the western boat with the last two releases of Monster Hunter only hitting Japan soil. They really need to make up some ground in the west and release Monster Hunter 4 at the same time or very close to its Japan release date of Spring 2013.
Bumeo has sent in a link to Forbes article “Why Capcom Needs To Bring ‘Monster Hunter’ To North American PS3 And Xbox 360 Owners“.
Personally I don’t think it has to come on a home console and a 3DS version would do very well outside of Japan provided it has some form of online play and is not dependent on Adhoc.
Another interesting link is one from product-reviews.net Capcom’s PS Vita mistake with Monster Hunter 4 (product-reviews.net)